Bacillus and hookworm: A billion could benefit
Hookworms, and other intestinal parasites known as helminths infect more than 1 billion people in poverty-stricken, tropical nations, sucking the vitality from the body, and leaving hundreds of millions of children physically and mentally stunted. Current drugs are insufficiently effective, and resistance is rising, but little effort has been made to develop better drugs because the relevant populations do not represent a profitable market for drug companies.
The benign crystal protein, produced naturally by bacteria and used as an organic pesticide, could be a safe, inexpensive treatment for parasitic worms in humans and provide effective relief to over a billion people around the world. Researchers from the University of California, San Diego, La Jolla, CA, have been looking at this potentially promising solution. “The challenge is that any cure must be very cheap, it must have the ability to be mass produced in tremendous quantities, safe, and able to withstand rough conditions, including lack of refrigeration, extreme heat, and remote locations,” says Raffi Aroian, a researcher on the study.
Adult male hookworm.
Image Dr. Yan Hu
In earlier research, Aroian and his collaborators described a protein, Cry5B, that can kill intestinal nematode parasites, such as human hookworms, in infected test animals (hamsters). Cry5B belongs to a family of proteins that are generally accepted as safe for humans. These proteins are produced naturally in Bacillus thuringiensis (Bt), a bacterium which is applied to crops as a natural insecticide. CryB proteins have also been engineered into food crops such as corn and rice, to render them pest resistant.
As shown for the first time in this research, Cry5B can also be expressed in Bacillus subtilis, which is closely related to Bacillus thuringiensis, and which is also related to bacteria which are present in some probiotics, says Aroian. In the current work researchers showed that a small dose of Cry5B, expressed in this bacterium can achieve a 93 percent elimination of hookworm parasites from infected hamsters. That, says Aroian, is substantially better than current drugs. The scientific significance of the research, he says, is that “bacteria similar to those that are food grade—which are cheap and can readily be mass produced—can be engineered to produce molecules that can cure parasitic diseases.”
Source: Provided by American Society for Microbiology. For more information see Appl. Environ. Microbiol. doi:10.1128/AEM.01854-13
Published in International Pest Control – September/October 2013 issue
Category: International Pest News
